Biomaterials are the evidence of advancements in engineering imbibing foundation of multidisciplinary nature the materials sciences and engineering. The stringent requirements mandate materials to sustain body’s immune response while being exposed to severe corrosive body environment with incidental thermal, mechanical and other unintended environmental shocks. Therein, various classes of material (ceramics, polymers, metals, composites) to attuning these as responsive materials (bioinert, bioactive, bioresorbable to toxic) to their judicious transition into structural and non-structural applications speaks volume of their diverse nature. Accordingly, metals (like stainless steel, Ti-6Al-4V, Co-Cr, etc.) have established itself as prime load-bearing materials, bioactive/bioinert ceramics (such as hydroxyapatite, zirconia, and bio-glass) have proven as exceptional material for bone-scaffolds, whereas polymers have exhibited supremacy for non-wetting surfaces for catheters, blood-bags, and liners for complying to the structural deformations during articulation of mating surfaces. Further, utilization of tailoring cytocompatibility using various additives along with simulated stimuli (i.e. electrical, magnetic or other chemicals) and sensing has led to accurate diagnostics in real time. Visualization of cell-material interaction have also paved a path for choosing the right material for intended biomedical applications. Real-time monitoring and incorporation of therapeutic agents to intervene real-time will strongly encourage use of technology in effective healing.